Benefits of NutraBio HMB (1000mg)
- Promotes lean muscle mass.
- Minimizes muscle breakdown.
- Enhances protein synthesis.
NutraBio HMB is a clinically proven ergogenic aid that has been shown in over 50 human studies to improve strength and power gains, increase lean mass, and aid recovery. HMB (short for beta-hydroxy beta-methylbutyrate) in an active metabolite of leucine that has both anticatabolic and anabolic properties. Due to these attributes HMB reduces muscle protein breakdown while also inducing muscle protein synthesis. This means HMB can lead to rapid strength gains in less time, significantly increase lean muscle mass, support more complete muscle recovery, and reduce muscle damage from resistance exercise. In fact, a recent position stand by the International Society of Sports Nutrition validates these claims. Based upon the comprehensive review of the HMB literature they concluded that HMB enhances muscle recovery by attenuating muscle damage; HMB increases muscle hypertrophy, strength, and power in trained and untrained populations when the appropriate exercise protocol is applied; HMB efficacy is manifested in young and old; and HMB is safe to consume.
HOW EXACTLY DOES HMB WORK?
HMB's main physiological functions are its capacity to stabilize the cell membrane of muscles, stimulation of protein synthesis and decrease of protein breakdown. The mechanism is related to HMB's role as an alternate substrate for cholesterol synthesis. The inhibition of cholesterol synthesis results in impaired muscle functions, increased muscular damage and finally, muscular necrosis. In order to maintain membrane integrity, muscle cells rely on cholesterol synthesis. Increased intramuscular HMB may provide readily available substrate for the synthesis of cholesterol needed to form and stabilize the muscle cell membrane. HMB has been shown to up-regulate muscle synthesis by the activation of the mTOR pathway, and to decrease muscle breakdown by influencing the ubiquitin-proteasome dependent pathways of protein degradation. Simply put HMB shifts the balance of protein synthesis, tipping the scale in muscle's favor. When protein synthesis equals protein breakdown, there is no net gain of muscle protein. This is important in maintaining/increasing strength. Therefore, the increase in protein synthesis and decrease in protein breakdown achieved through HMB supplementation results in greater strength gains and faster recovery via net gains in muscle protein.
HOW TO TAKE HMB
The recommended dosage of HMB is three grams per day for average-size individuals. If you want to "customize" your dosage, research has shown that 38 mg per kg or 17 mg per pound of body weight each day is optimal (see chart for simplified dosage scale). You should divide the daily dosage into two or three equal servings and take these servings spread out over the day.
| Weight |
Daily Dosage of HMB |
| 140 lbs. |
2.5g |
| 170 lbs. |
3.0g |
| 200 lbs. |
3.5g |
| 230 lbs. |
4.0g |
| 260 lbs. |
4.5g |
| 290 lbs. |
5.0g |
| (Each 30 lbs. increment) |
500mg or 0.5g |
|
|
In regards to HMB timing near or around a training session, we recommend that you take one of your daily servings of HMB an hour before exercise to help reduce muscle damage. If you are unable to take HMB prior to exercise, then take a dose immediately after your workout or training session. For example, if your workout in the evening, take one serving in the morning and one an hour before your evening workout. If you workout in the morning, take your first serving right before or after your morning workout and a second serving at night.
